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simulated intestinal fluid (sif)  (Ricca Chemical Company)

 
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    Ricca Chemical Company simulated intestinal fluid (sif)
    Simulated Intestinal Fluid (Sif), supplied by Ricca Chemical Company, used in various techniques. Bioz Stars score: 90/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
    https://www.bioz.com/product/fluid+sif/pm39674455-49-7-12?v=Ricca+Chemical+Company
    Average 90 stars, based on 1 article reviews
    simulated intestinal fluid (sif) - by Bioz Stars, 2026-07
    90/100 stars

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    simulated intestinal fluid (sif)  (Ricca Chemical Company)
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    Preparation of nanoCEL and its immune‐modulation properties in vitro. (A) Schematic fabrication of nanoCEL; (B) Effect of drug/polymer feed ratio on the mean particle size and polydispersity index (PDI) of nanoCEL; (C) The optical (inset) and TEM images of nanoCEL; (D) Particle size distribution, zeta potential, loading capacity (LC), and encapsulation efficiency (EE) of nanoCEL; (E) In vitro release profiles of nanoCEL under varied pH conditions (PBS, pH = 1.5, 4.5, and 7.5) at 37°C for 120 h (n = 3; ** p < 0.01, *** p < 0.001 vs. pH = 1.5); (F) In vitro stability of nanoCEL in simulated gastric fluid (SGF) at 37°C for 2 h, followed by <t>simulated</t> <t>intestinal</t> <t>fluid</t> <t>(SIF)</t> at 37°C for 6 h (n = 3); (G) CLMS images and flow cytometry analysis of JAWSII dendritic cell uptake of various formulations after incubation for 15 min. Nile Red (NR) fluorescence is depicted in red. (n = 6; ns indicates no significance, *** p < 0.001 vs. blank group); (H) IL‐6, IL‐12p70, and CXCL5 levels in the cell culture medium of LPS‐stimulated JAWSII dendritic cells after treatment with 200 n m free CEL and 200 n m nanoCEL; cells without any manipulation set as blank group (n = 4; *** p < 0.001 vs. LPS‐stimulated group; ### p < 0.001). (I) NO, IL‐6, and TNF‐α levels in the cell culture medium of LPS‐stimulated RAW264.7 macrophages after treatment with 200 n m free CEL and 200 n m nanoCEL; cells without any manipulation set as blank group (n = 4; *** p < 0.001 vs. LPS‐stimulated group; ### p < 0.001). (J) Western blot analysis of CD206 and Arg‐1 levels from each group (n = 3; *** p < 0.001 vs. LPS‐stimulated group; ### p < 0.001).
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    Preparation of nanoCEL and its immune‐modulation properties in vitro. (A) Schematic fabrication of nanoCEL; (B) Effect of drug/polymer feed ratio on the mean particle size and polydispersity index (PDI) of nanoCEL; (C) The optical (inset) and TEM images of nanoCEL; (D) Particle size distribution, zeta potential, loading capacity (LC), and encapsulation efficiency (EE) of nanoCEL; (E) In vitro release profiles of nanoCEL under varied pH conditions (PBS, pH = 1.5, 4.5, and 7.5) at 37°C for 120 h (n = 3; ** p < 0.01, *** p < 0.001 vs. pH = 1.5); (F) In vitro stability of nanoCEL in simulated gastric fluid (SGF) at 37°C for 2 h, followed by <t>simulated</t> <t>intestinal</t> <t>fluid</t> <t>(SIF)</t> at 37°C for 6 h (n = 3); (G) CLMS images and flow cytometry analysis of JAWSII dendritic cell uptake of various formulations after incubation for 15 min. Nile Red (NR) fluorescence is depicted in red. (n = 6; ns indicates no significance, *** p < 0.001 vs. blank group); (H) IL‐6, IL‐12p70, and CXCL5 levels in the cell culture medium of LPS‐stimulated JAWSII dendritic cells after treatment with 200 n m free CEL and 200 n m nanoCEL; cells without any manipulation set as blank group (n = 4; *** p < 0.001 vs. LPS‐stimulated group; ### p < 0.001). (I) NO, IL‐6, and TNF‐α levels in the cell culture medium of LPS‐stimulated RAW264.7 macrophages after treatment with 200 n m free CEL and 200 n m nanoCEL; cells without any manipulation set as blank group (n = 4; *** p < 0.001 vs. LPS‐stimulated group; ### p < 0.001). (J) Western blot analysis of CD206 and Arg‐1 levels from each group (n = 3; *** p < 0.001 vs. LPS‐stimulated group; ### p < 0.001).
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    Preparation of nanoCEL and its immune‐modulation properties in vitro. (A) Schematic fabrication of nanoCEL; (B) Effect of drug/polymer feed ratio on the mean particle size and polydispersity index (PDI) of nanoCEL; (C) The optical (inset) and TEM images of nanoCEL; (D) Particle size distribution, zeta potential, loading capacity (LC), and encapsulation efficiency (EE) of nanoCEL; (E) In vitro release profiles of nanoCEL under varied pH conditions (PBS, pH = 1.5, 4.5, and 7.5) at 37°C for 120 h (n = 3; ** p < 0.01, *** p < 0.001 vs. pH = 1.5); (F) In vitro stability of nanoCEL in simulated gastric fluid (SGF) at 37°C for 2 h, followed by <t>simulated</t> <t>intestinal</t> <t>fluid</t> <t>(SIF)</t> at 37°C for 6 h (n = 3); (G) CLMS images and flow cytometry analysis of JAWSII dendritic cell uptake of various formulations after incubation for 15 min. Nile Red (NR) fluorescence is depicted in red. (n = 6; ns indicates no significance, *** p < 0.001 vs. blank group); (H) IL‐6, IL‐12p70, and CXCL5 levels in the cell culture medium of LPS‐stimulated JAWSII dendritic cells after treatment with 200 n m free CEL and 200 n m nanoCEL; cells without any manipulation set as blank group (n = 4; *** p < 0.001 vs. LPS‐stimulated group; ### p < 0.001). (I) NO, IL‐6, and TNF‐α levels in the cell culture medium of LPS‐stimulated RAW264.7 macrophages after treatment with 200 n m free CEL and 200 n m nanoCEL; cells without any manipulation set as blank group (n = 4; *** p < 0.001 vs. LPS‐stimulated group; ### p < 0.001). (J) Western blot analysis of CD206 and Arg‐1 levels from each group (n = 3; *** p < 0.001 vs. LPS‐stimulated group; ### p < 0.001).
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    Preparation of nanoCEL and its immune‐modulation properties in vitro. (A) Schematic fabrication of nanoCEL; (B) Effect of drug/polymer feed ratio on the mean particle size and polydispersity index (PDI) of nanoCEL; (C) The optical (inset) and TEM images of nanoCEL; (D) Particle size distribution, zeta potential, loading capacity (LC), and encapsulation efficiency (EE) of nanoCEL; (E) In vitro release profiles of nanoCEL under varied pH conditions (PBS, pH = 1.5, 4.5, and 7.5) at 37°C for 120 h (n = 3; ** p < 0.01, *** p < 0.001 vs. pH = 1.5); (F) In vitro stability of nanoCEL in simulated gastric fluid (SGF) at 37°C for 2 h, followed by simulated intestinal fluid (SIF) at 37°C for 6 h (n = 3); (G) CLMS images and flow cytometry analysis of JAWSII dendritic cell uptake of various formulations after incubation for 15 min. Nile Red (NR) fluorescence is depicted in red. (n = 6; ns indicates no significance, *** p < 0.001 vs. blank group); (H) IL‐6, IL‐12p70, and CXCL5 levels in the cell culture medium of LPS‐stimulated JAWSII dendritic cells after treatment with 200 n m free CEL and 200 n m nanoCEL; cells without any manipulation set as blank group (n = 4; *** p < 0.001 vs. LPS‐stimulated group; ### p < 0.001). (I) NO, IL‐6, and TNF‐α levels in the cell culture medium of LPS‐stimulated RAW264.7 macrophages after treatment with 200 n m free CEL and 200 n m nanoCEL; cells without any manipulation set as blank group (n = 4; *** p < 0.001 vs. LPS‐stimulated group; ### p < 0.001). (J) Western blot analysis of CD206 and Arg‐1 levels from each group (n = 3; *** p < 0.001 vs. LPS‐stimulated group; ### p < 0.001).

    Journal: Advanced Science

    Article Title: Oral Celastrol Nanomedicine Targeting Intestinal Antigen‐Presenting Cells to Effectively Mitigate Autoimmune Uveitis via Gut‐Retina Axis

    doi: 10.1002/advs.202519503

    Figure Lengend Snippet: Preparation of nanoCEL and its immune‐modulation properties in vitro. (A) Schematic fabrication of nanoCEL; (B) Effect of drug/polymer feed ratio on the mean particle size and polydispersity index (PDI) of nanoCEL; (C) The optical (inset) and TEM images of nanoCEL; (D) Particle size distribution, zeta potential, loading capacity (LC), and encapsulation efficiency (EE) of nanoCEL; (E) In vitro release profiles of nanoCEL under varied pH conditions (PBS, pH = 1.5, 4.5, and 7.5) at 37°C for 120 h (n = 3; ** p < 0.01, *** p < 0.001 vs. pH = 1.5); (F) In vitro stability of nanoCEL in simulated gastric fluid (SGF) at 37°C for 2 h, followed by simulated intestinal fluid (SIF) at 37°C for 6 h (n = 3); (G) CLMS images and flow cytometry analysis of JAWSII dendritic cell uptake of various formulations after incubation for 15 min. Nile Red (NR) fluorescence is depicted in red. (n = 6; ns indicates no significance, *** p < 0.001 vs. blank group); (H) IL‐6, IL‐12p70, and CXCL5 levels in the cell culture medium of LPS‐stimulated JAWSII dendritic cells after treatment with 200 n m free CEL and 200 n m nanoCEL; cells without any manipulation set as blank group (n = 4; *** p < 0.001 vs. LPS‐stimulated group; ### p < 0.001). (I) NO, IL‐6, and TNF‐α levels in the cell culture medium of LPS‐stimulated RAW264.7 macrophages after treatment with 200 n m free CEL and 200 n m nanoCEL; cells without any manipulation set as blank group (n = 4; *** p < 0.001 vs. LPS‐stimulated group; ### p < 0.001). (J) Western blot analysis of CD206 and Arg‐1 levels from each group (n = 3; *** p < 0.001 vs. LPS‐stimulated group; ### p < 0.001).

    Article Snippet: Simulated gastric fluid (SGF) and simulated intestinal fluid (SIF) were purchased from Shanghai Yuanye Bio‐Technology Co., Ltd (Shanghai, China).

    Techniques: In Vitro, Polymer, Zeta Potential Analyzer, Encapsulation, Flow Cytometry, Incubation, Fluorescence, Cell Culture, Western Blot